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Wickerhamomyces Anomalus Postoperative Endophthalmitis.
Antonio Galván Ledesma1, Mariano Rodríguez Maqueda1, Arturo Talego Sancha1
1Department of Ophthalmology, Virgen Del Rocío University Hospital, Seville, Spain.
Ocular Immunology and Inflammation
|September 27, 2022
Summary
This report details a rare case of postoperative fungal endophthalmitis caused by Wickerhamomyces anomalus. Treatment involved oral antifungal therapy and intraocular lens explantation, successfully controlling the ocular infection.
Area of Science:
- Ophthalmology
- Mycology
- Infectious Diseases
Background:
- Postoperative endophthalmitis is a serious complication following ocular surgery.
- Fungal endophthalmitis is less common than bacterial but can be challenging to treat.
- Wickerhamomyces anomalus is an opportunistic yeast rarely implicated in ocular infections.
Observation:
- A patient developed chronic endophthalmitis after cataract surgery with inadvertent ocular perforation.
- The infection was characterized by dense hemovitreous and retinal detachment.
- Wickerhamomyces anomalus was identified after multiple surgeries and treatments.
Findings:
- Wickerhamomyces anomalus demonstrated resistance to multiple vitreoretinal surgeries and intravitreal antibiotics.
- Combined treatment with oral voriconazole and intraocular lens (IOL) explantation led to infection control.
- This represents the second reported case of Wickerhamomyces anomalus endophthalmitis.
Implications:
- A high index of suspicion is crucial for diagnosing fungal endophthalmitis.
- IOL explantation combined with systemic antifungal therapy may be an effective treatment strategy for Wickerhamomyces anomalus endophthalmitis.
- Further research is needed to understand the pathogenicity and optimal treatment of rare fungal causes of endophthalmitis.
