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Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
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Assessing HD-EEG functional connectivity states using a human brain computational model.

Judie Tabbal1,2, Aya Kabbara3,2, Maxime Yochum4

  • 1Institute of Clinical Neurosciences of Rennes (INCR), Rennes, France.

Journal of Neural Engineering
|September 27, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces a computational framework for optimizing electroencephalography/magnetoencephalography (EEG/MEG) network analysis. It quantifies pipeline steps, identifying weighted minimum norm estimate/Phase Locking Value and ICA as effective for dynamic brain network states.

Keywords:
brain networks statesdynamic functional connectivityelectroencephalographyneural mass models

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Biophysics

Background:

  • Electro/Magnetoencephalography (EEG/MEG) source-space network analysis tracks fast brain dynamics.
  • Evaluating EEG/MEG pipeline steps lacks realistic, controlled data.

Purpose of the Study:

  • Quantitatively assess advantages and limitations of EEG/MEG network analysis techniques.
  • Introduce a framework to optimize the entire EEG/MEG source connectivity pipeline.

Main Methods:

  • Utilized a human brain computational model with physiologically based circuits and Diffusion Tensor Imaging to generate EEG data.
  • Simulated gamma-band oscillations for a virtual picture-naming task.
  • Evaluated inverse models, functional connectivity measures, and dimensionality reduction for brain network states (BNS).

Main Results:

  • Significant variability found among decomposition techniques in spatial and temporal accuracy.
  • Outlined spatial precision, temporal sensitivity, and global accuracy of extracted BNS.
  • Weighted minimum norm estimate/Phase Locking Value and ICA showed good performance for functional networks and dynamic BNS.

Conclusions:

  • Brain models can further evaluate EEG/MEG source-space network analysis steps.
  • Reduces empirical selection of pipeline methods due to their considerable impact on results.
  • Framework aids in optimizing EEG/MEG source connectivity analysis.