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The medial temporal lobe structure and function support positive affect.

Weipeng Jin1, Jie Feng2, Wenwei Zhu2

  • 1Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, 300060, China.

Neuropsychologia
|September 27, 2022
PubMed
Summary
This summary is machine-generated.

Positive affect is linked to brain structure and function. The perirhinal cortex volume and its connectivity with the fronto-parietal system are key to individual differences in positive affect.

Keywords:
HippocampusMultivariate pattern analysisPerirhinal cortexPositive affectVBM

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Positive affect (PA) is crucial for psychological and physical health, influencing cognitive processes.
  • The role of medial temporal lobe (MTL) structures and their connectivity in individual variability of PA is not well understood.

Purpose of the Study:

  • To investigate the morphological (grey matter volume; GMV) and functional (resting-state functional connectivity; rsFC) characteristics of the MTL and its subfields related to individual differences in PA.
  • To explore the neuroanatomical and functional substrates underlying human PA trait.

Main Methods:

  • Utilized univariate and multivariate pattern analyses (MVPA) on a large sample (n=321).
  • Collected T1-weighted, high-resolution MTL T2-weighted, and resting-state functional imaging data.
  • Employed automatic segmentation of hippocampal subfields (ASHS) software for MTL subfield volume extraction.

Main Results:

  • Multivariate pattern analysis revealed associations between GMVs in prefrontal-occipital and limbic systems and PA.
  • Linear regression showed a positive association between MTL subfield GMV, particularly the right perirhinal cortex (PRC), and PA.
  • PRC-seed-based rsFC analyses indicated that couplings with the fronto-parietal-occipital system predicted PA.

Conclusions:

  • The study highlights the critical contribution of the MTL, specifically the perirhinal cortex (PRC), but not hippocampal subfields, to the formation of PA.
  • Functional connectivity of the PRC with the fronto-parietal control system is a significant predictor of PA.
  • Findings offer novel insights into the neuroanatomical and functional basis of positive affect traits.