Apoptotic bodies for advanced drug delivery and therapy

Area of Science:

• Biomedical Science
• Cell Biology
• Nanotechnology

Background:

• Extracellular vesicles (EVs) are key mediators in cell-to-cell communication.
• Apoptotic bodies (ABs) are a major class of EVs derived from cells undergoing apoptosis.
• ABs possess unique characteristics, including larger size and high biomolecule content, making them promising for biomedical uses.

Purpose of the Study:

• To provide a comprehensive overview of current knowledge regarding apoptotic bodies (ABs).
• To summarize the applications of AB-based strategies in disease diagnosis and therapy.
• To highlight future perspectives for ABs in diverse biomedical applications.

Main Methods:

• Literature review and synthesis of existing research on apoptotic bodies.
• Analysis of the properties and functions of ABs in biological systems.
• Evaluation of current and emerging applications of ABs in diagnostics and therapeutics.

Main Results:

• Apoptotic bodies (ABs) inherit properties from parent cells, offering stability and rich biomolecular cargo.
• Their surface characteristics and size facilitate recipient cell recognition and interaction.
• ABs demonstrate potential in modulating disease symptoms due to their biocompatibility and origin.

Conclusions:

• Apoptotic bodies (ABs) represent a versatile platform for biomedical applications, including diagnostics, immunotherapy, regenerative medicine, and drug delivery.
• Further research into AB-based strategies is crucial for advancing their clinical translation.
• ABs hold significant promise for future innovations in personalized medicine and disease management.