Related Experiment Video
Updated: Aug 27, 2025

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
Published on: March 14, 2019
Hypercalcaemia caused by calcium sulfate beads
Samuel Epstein1, Diego E Vanegas Acosta2
1College of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
Abstract:
Hypercalcaemia is a relatively common metabolic disturbance seen in hospitalised patients; however, given the complicated systems of calcium regulation, it can take a significant amount of time and testing to pinpoint the aetiology. This case discusses a patient who developed acute hypercalcaemia from calcium sulfate-containing antibiotic beads placed during an orthopaedic procedure. These beads are used in surgical procedures to fill gaps/voids in bony structures and for local delivery of antibiotics. The case highlights the importance of careful review of a patient's hospital course, including the administration of medical products that may not be clearly documented on a patient's medicine administration record when working up an unexplained finding.
Related Concept Videos
Skeleton and Calcium Homeostasis
Urinary Tract Calculi I: Introduction
Urinary Tract Calculi III: Medical Management
Sulfate Attack on Concrete
Sulfates from sources like soil, groundwater, or industrial effluents...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Urinary Tract Calculi IV: Nutrition Therapy and Prevention

