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The stem cell-specific long non-coding RNAs in leukemia
Maryam Farzaneh1, Sajad Najafi2, Mohadeseh Sheykhi-Sabzehpoush3
1Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Long non-coding RNAs (lncRNAs) are implicated in leukemia stem cell (LSC) survival and proliferation. Understanding lncRNAs offers new prognostic, diagnostic, and therapeutic strategies for leukemia.
Area of Science:
- Hematology
- Molecular Biology
- Oncology
Background:
- Leukemia is a rising global health concern with incompletely understood causes.
- Leukemia stem cells (LSCs) drive cancer growth and resist conventional treatments.
- Altered long non-coding RNA (lncRNA) expression is observed in LSCs, impacting their biology.
Purpose of the Study:
- To review the role of lncRNAs in the pathogenesis of leukemia stem cells.
- To discuss the prognostic, diagnostic, and therapeutic potential of lncRNAs in leukemia.
Main Methods:
- Literature review of recent studies on lncRNAs and LSCs.
- Analysis of lncRNA functions in LSC survival, proliferation, and differentiation.
- Evaluation of lncRNAs as biomarkers and therapeutic targets in leukemia.
Main Results:
- lncRNAs play a critical role in LSC maintenance and resistance to therapy.
- Aberrant lncRNA expression is linked to leukemia progression.
- lncRNAs demonstrate potential as prognostic indicators and therapeutic targets.
Conclusions:
- lncRNAs are significantly involved in leukemia stem cell pathogenesis.
- lncRNAs hold promise for improving leukemia diagnosis, prognosis, and treatment strategies.
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