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After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
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Related Experiment Video

Updated: Aug 27, 2025

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
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Platelet aggregation in normal pregnancy.

Xiaoling Su1, Weixiu Zhao1

  • 1Department of Obstetrics and Gynecology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|September 28, 2022
PubMed
Summary

Platelet aggregation (PA) is higher in normal pregnancy, with a reference range of 74.75%-94.77%. Albumin and platelet distribution width may influence PA during pregnancy.

Keywords:
AlbuminNormal pregnancyPlatelet aggregationPlatelet countsPlatelet distribution widthReference interval

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Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Clinical Chemistry

Background:

  • Abnormal platelet aggregation (PA) is implicated in adverse pregnancy outcomes.
  • Establishing reference ranges for PA in normal pregnancy is crucial.
  • Factors influencing PA in pregnancy require further investigation.

Purpose of the Study:

  • To determine the reference range for PA in normal pregnancy.
  • To compare PA levels between pregnant and non-pregnant individuals.
  • To identify factors associated with PA in pregnancy.

Main Methods:

  • Assessed PA in 150 pregnant participants (second trimester) and 38 non-pregnant controls.
  • Measured hemoglobin (Hb), platelet counts (PLT), albumin (Alb), platelet distribution width (PDW), and mean platelet volume.
  • Utilized linear regression models (LRM) to analyze correlations.

Main Results:

  • PA was significantly higher in normal pregnancy (84.40%) compared to controls (80.7%, P=0.013).
  • The reference interval for PA in normal pregnancy was established as 74.75%-94.77%.
  • PA showed positive correlation with PLT and negative correlation with PDW and mean platelet volume. Albumin and PDW were significant factors in LRM.

Conclusions:

  • Platelet aggregation is enhanced in normal pregnancy.
  • Albumin and platelet distribution width are potential contributing factors to PA in pregnancy.