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Updated: Aug 27, 2025

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Two-photon absorption-based delivery of nitric oxide from ruthenium nitrosyl complexes
Pascal G Lacroix1, Isabelle Malfant1, Pablo Labra-Vázquez1,2
1Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077 Toulouse, France. pascal.lacroix@lcc-toulouse.fr.
Abstract:
Since the discovery of the numerous physiological roles exhibited by nitric oxide (NO), ruthenium nitrosyl (RuNO) complexes have been regarded as one of the most promising NO donors, stable, well tolerated by the body and capable of releasing NO locally and quantitatively, under light irradiation. This release can be achieved by two-photon absorption (TPA) processes, which allow the irradiation to be performed in the near infrared domain, where light has its maximum depth of penetration in biological tissues. This review provides a short introduction on the biological properties of NO, on RuNO complexes with photo-releasing capabilities, and on the origin of TPA properties in molecules. Then, the RuNO complexes with TPA capabilities are thoroughly discussed either as monometallic or polymetallic species.
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