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[Therapeutic possibilities of using phosphocreatine in complicated myocardial infarct]
Insights
Phosphocreatine therapy improved outcomes for patients with complicated myocardial infarction (MI). This treatment reduced heart failure symptoms and stabilized cardiac rhythm, offering a favorable effect on disease course.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Complicated myocardial infarction (MI) presents with life-threatening arrhythmias and congestive heart failure.
- Concomitant pathologies often complicate the management of MI patients.
Purpose of the Study:
- To investigate the therapeutic effect of Phosphocreatine (PC) in patients with complicated myocardial infarction.
- To evaluate the impact of PC therapy on clinical symptoms, cardiac rhythm, contractility, and gas exchange.
Main Methods:
- A study involving 40 patients with complicated MI, including those with arrhythmias and heart failure (II-IV degree).
- Administered intravenous Phosphocreatine (PC) infusions over 3 days at a total dose of 144g.
- Compared outcomes with 173 MI patients receiving routine therapy.
Main Results:
- PC therapy led to a reduction in heart failure symptoms in 26 patients and stabilized cardiac rhythm in 23 patients.
- A positive inotropic effect of PC was observed, preserving heart contractility at a higher level.
- Improved gas exchange was noted in patients receiving PC compared to routine therapy.
Conclusions:
- Phosphocreatine (PC) therapy demonstrates a favorable effect on the course of complicated myocardial infarction.
- PC therapy can alleviate clinical symptoms, improve cardiac function, and enhance gas exchange in MI patients.
Abstract:
A total of 40 patients with complicated myocardial infarction (MI), with life threatening arrhythmias and congestive heart failure. II-IV degree after Walk's classification, with a concomitant pathology were investigated. Phosphocreatine (PC) therapy (i. v. infusions for 3 days at a total dose of 144 g) made a positive effect on a course of disease. A degree of clinical symptoms of heart failure lessened in 26 patients, disturbed cardiac rhythm got stable in 23 patients. A PC positively inotropic effect was observed. The comparison of the results of PC therapy with those of 173 MI patients on routine therapy showed heart contractility preserved at a higher level and the improvement of gas exchange. A conclusion was made of a favorable effect of the drug on a course of complicated MI.