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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Long-term neurological outcomes in premature children with excitotoxic brain damage]
O A Savchenko1, E B Pavlinova1
1Omsk State Medical University, Omsk, Russia.
Objective:
To establish the prognostic significance of a biomarker of excitotoxic brain damage (antibodies to the NR2 subunit of the N-methyl-D-aspartate (NMDA) glutamate receptor) as a predictor of damage to the central nervous system (CNS) in preterm infants.
Material And Methods:
24 newborns with a gestational age of 24-33 weeks were examined with the determination of the level of antibodies to the NR2 subunit of the NMDA glutamate receptor on the 21st day of life.
Results:
In the course of the study, it was found that the level of antibodies to the NR2 subunit of the NMDA glutamate receptor on the 21st day of life, in combination with the level of cord blood lactate and the resistance of cerebral vessels on the 1st day of life, can be predictors of CNS damage in a premature baby at the age of 1 month of corrected age. Predictors of an unfavorable neurological outcome at the age of 1 year of corrected age in a premature baby with perinatal CNS damage are the level of cord blood lactate and antibodies to the NR2 subunit of the NMDA glutamate receptor, determined on the 21st day of life in a newborn.
Conclusion:
The biomarker of excitotoxic brain damage can be a predictor of long-term neurological outcome and determine the amount, type and duration of neuroprotective care for premature infants.
