Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.9K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

463
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
463
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

431
The pathophysiology of pneumonia involves the following steps:
431
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

533
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
533
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

2.8K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.8K
Infection01:20

Infection

8.6K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pglyrp1-Cre marks distinct epithelial and immune lineages across mucosal sites.

ImmunoHorizons·2026
Same author

Cough biomarkers for diagnosis and monitoring of respiratory disease: a systematic review.

European respiratory review : an official journal of the European Respiratory Society·2026
Same author

CMPK2 restricts <i>Mycobacterium tuberculosis</i> replication and regulates macrophage gene expression.

bioRxiv : the preprint server for biology·2026
Same author

Neurologic mechanisms regulating cough in health and disease.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2026
Same author

Sorting nexin 5 mediates antigen presentation and immunity against <i>Mycobacterium tuberculosis</i>.

bioRxiv : the preprint server for biology·2026
Same author

HIV impairs and exploits pulmonary Th17 and Th22 cell-mediated immune responses to Mycobacterium tuberculosis.

PLoS pathogens·2026

Related Experiment Video

Updated: Aug 27, 2025

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

729

Infectious and Inflammatory Pathways to Cough.

Kubra F Naqvi1, Stuart B Mazzone2, Michael U Shiloh1,3

  • 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA;

Annual Review of Physiology
|September 28, 2022
PubMed
Summary

Coughing, a protective reflex, can spread respiratory infections. This review explores the neurophysiology of cough, how pathogens induce it, and its role in disease transmission.

Keywords:
coughdisease transmissionrespiratory tract infectionssensory neurons

More Related Videos

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
05:43

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Published on: January 10, 2025

738
Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

7.7K

Related Experiment Videos

Last Updated: Aug 27, 2025

Methods for Detecting Cough and Airway Inflammation in Mice
04:33

Methods for Detecting Cough and Airway Inflammation in Mice

Published on: August 2, 2024

729
Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid
05:43

Establishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid

Published on: January 10, 2025

738
Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

7.7K

Area of Science:

  • Neuroscience
  • Immunology
  • Respiratory Medicine

Background:

  • Coughing is a vital physiological reflex for airway clearance.
  • Respiratory pathogens and inflammation can trigger cough by interacting with sensory neurons.
  • Coughing facilitates the transmission of infectious diseases.

Purpose of the Study:

  • To review the neurophysiology of cough.
  • To examine how respiratory pathogens and inflammation induce cough.
  • To summarize cough-mediated disease transmission.

Main Methods:

  • Literature review of neurophysiology.
  • Analysis of pathogen-induced cough mechanisms.
  • Examination of aerosol transmission studies.

Main Results:

  • Vagal sensory neurons and airway irritation are key to cough induction.
  • Microbial components and inflammatory mediators activate cough reflex.
  • Cough-generated aerosols are a significant route for infectious disease spread.

Conclusions:

  • Understanding cough neurophysiology is crucial for managing respiratory infections.
  • Targeting cough induction pathways may reduce disease transmission.
  • Cough plays a dual role in airway protection and pathogen dissemination.