Infectious and Inflammatory Pathways to Cough
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Updated: Aug 27, 2025

Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
Kubra F Naqvi1, Stuart B Mazzone2, Michael U Shiloh1,3
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA;
Abstract:
Coughing is a dynamic physiological process resulting from input of vagal sensory neurons innervating the airways and perceived airway irritation. Although cough serves to protect and clear the airways, it can also be exploited by respiratory pathogens to facilitate disease transmission. Microbial components or infection-induced inflammatory mediators can directly interact with sensory nerve receptors to induce a cough response. Analysis of cough-generated aerosols and transmission studies have further demonstrated how infectious disease is spread through coughing. This review summarizes the neurophysiology of cough, cough induction by respiratory pathogens and inflammation, and cough-mediated disease transmission.
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