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Evaluation of the Storage Stability of Extracellular Vesicles
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Emerging role of extracellular vesicles in kidney diseases

Huiling Xiang1, Chun Zhang1, Jing Xiong1

  • 1Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Pharmacology
|September 29, 2022
PubMed

Insights

Extracellular vesicles (EVs) are key in kidney disease progression and treatment. This review explores their role, offering new therapeutic targets for renal diseases.

Area of Science:

  • Nephrology
  • Cell Biology
  • Biochemistry

Background:

  • Kidney diseases significantly burden global healthcare, often progressing to end-stage renal disease requiring renal replacement therapy.
  • Despite research advances, effective treatments for kidney diseases remain elusive.
  • Extracellular vesicles (EVs), containing proteins, lipids, and nucleic acids, mediate intercellular communication and influence cell phenotypes.

Purpose of the Study:

  • To review the latest research on extracellular vesicles (EVs) in the context of renal diseases.
  • To elucidate the mechanisms and potential therapeutic applications of EVs in kidney disease.
  • To identify novel therapeutic targets and strategies for renal diseases based on EV research.

Main Methods:

  • Literature review of recent studies on EVs and kidney diseases.
  • Analysis of the role of EVs in the occurrence, development, and treatment of renal diseases.
  • Synthesis of current understanding regarding EV production, content, and transport in renal contexts.

Main Results:

  • EVs play a significant role in the pathogenesis and progression of various kidney diseases.
  • EVs facilitate intercellular communication, influencing the phenotype of recipient cells in renal tissues.
  • The precise mechanisms and therapeutic potential of EVs in kidney diseases require further investigation.

Conclusions:

  • Extracellular vesicles represent a promising area for developing new therapeutic strategies for renal diseases.
  • Understanding EV function in kidney disease can lead to novel treatment targets.
  • Further research is needed to fully harness the potential of EVs for treating kidney diseases.
Keywords:
chronic kidney diseaseexosomesextracellular vesicleskidney diseasesurinary extracellular vesicles

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