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Role of microRNAs in type 2 diseases and allergen-specific immunotherapy

Constanze A Jakwerth1, Hannah Kitzberger1, Dimitrii Pogorelov1

  • 1Center of Allergy / Environment (ZAUM), Technical University of Munich, School of Medicine and Helmholtz Center Munich, German Research Center for Environmental Health, Member of the German Center for Lung Research (DZL), Member of the Immunology and Inflammation Initiative of the Helmholtz Association, Munich, Germany.

Frontiers in Allergy
|September 29, 2022
PubMed

Insights

MicroRNAs (miRs) are key regulators in allergic diseases and potential biomarkers for allergen-specific immunotherapy (AIT). This review explores their role in immune responses and therapeutic mechanisms.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRs) are critical post-transcriptional regulators involved in cellular processes.
  • Dysregulated miR expression contributes to the pathophysiology of various diseases, including allergic conditions.
  • MiRs hold potential as biomarkers for diagnosing and treating allergic diseases.

Purpose of the Study:

  • To review current research on the role of specific miRs in immune responses.
  • To explore miR regulation in allergic diseases.
  • To elucidate the connection between miRs and allergen-specific immunotherapy (AIT) mechanisms.

Main Methods:

  • Literature review of current research on microRNAs in allergic diseases and immunotherapy.
  • Analysis of miR function in epithelial and immune cells.
  • Examination of miR involvement in immune response regulation.

Main Results:

  • Specific miRs play significant roles in regulating immune responses in epithelial and immune cells.
  • MiRs are implicated in the development and progression of allergic diseases.
  • Understanding miR mechanisms is crucial for advancing allergen-specific immunotherapy.

Conclusions:

  • MicroRNAs are integral to the immune system's response in allergic diseases.
  • Further research into miRs can uncover novel therapeutic targets for AIT.
  • This review highlights the current knowledge gaps and future directions in miR research for allergy treatment.
Keywords:
airway epithelial cells (AECs)allergen specific immunotherapy (ASIT)immune crosstalkinduced sputummicroRNAnasal secretionstype 2 inflammationvenom immunotherapy (VIT)

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