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Education level may modify the association between cardiac index and cognitive function among elders with normal

Hao-Min Cheng1,2, Shao-Yuan Chuang3, Yu-Ting Ko1

  • 1Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan.

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Summary
This summary is machine-generated.

Higher cardiac index (CI) in older adults is linked to better cognitive function, especially in those with lower education. Increased arterial stiffness negatively impacts cognition across all education levels.

Keywords:
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Area of Science:

  • Cardiology
  • Neurology
  • Gerontology

Background:

  • Lower cardiac index (CI) is associated with dementia in elders.
  • Higher CI may protect against brain aging.
  • The influence of education and arterial stiffness on CI and cognition is unclear.

Purpose of the Study:

  • To investigate how education level and arterial stiffness modulate the association between CI and cognitive function in older adults.
  • To determine if CI is associated with cognitive function in elders with normal ejection fraction.
  • To explore the relationship between arterial stiffness, CI, and cognitive decline.

Main Methods:

  • 723 elders (≥60 years) with normal ejection fraction were analyzed.
  • Cardiac index (CI) was derived from Doppler stroke volume.
  • Arterial stiffness (carotid-femoral pulse wave velocity) and cognitive function (Mini-Mental Short Examination) were measured; education level was recorded.

Main Results:

  • Higher CI correlated positively with cognitive function (MMSE) and reduced risk of low MMSE.
  • These associations were significant in elders with 9 or fewer years of education.
  • Higher arterial stiffness was linked to lower cognitive function in all participants.

Conclusions:

  • Higher CI is linked to better cognitive function in elders, particularly those with lower education.
  • Arterial stiffness independently predicts cognitive decline.
  • Education level may influence the protective effects of CI on cognition.