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Updated: Aug 27, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Using a knowledge translation program to facilitate guideline- and evidence-based patient management: the PAH-QuERI
Vallerie V McLaughlin1, Richard N Channick2, Karimah S Bell Lynum3
1Pulmonary Hypertension Program University of Michigan Health System Ann Arbor Michigan USA.
Abstract:
The Pulmonary Arterial Hypertension-Quality Enhancement Research Initiative Extension Program was designed to support physicians' adherence to pulmonary arterial hypertension (PAH) guidelines. Guidelines were followed in >95% of patients with functional class (FC) II/III, but for only 28.6% of FC IV patients (Month 36). Low adherence was driven by FC IV patients' preference to avoid parenteral treatment.
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