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Updated: Aug 27, 2025

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
An electrochemical tandem Michael addition, azidation and intramolecular cyclization strategy for the synthesis of
Kai Zhou1, Shendan Xia1, Yanming Liu1
1College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China. chenzhiwei@zjut.edu.cn.
Abstract:
An electrochemical-oxidation-induced intramolecular annulation used for the synthesis of imidazole was developed under undivided electrolytic conditions. In an undivided cell, amines, alkynes and azides could smoothly participate in the transformation to furnish a variety of substituted imidazoles through the tandem Michael addition/azide/cycloamine reaction. The reaction could be easily handled and avoided the use of both transition metal catalysts and peroxide reagents, which is in line with the concept of green chemistry.
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