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Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
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Grouped Spherical Data Modeling Through Hierarchical Nonparametric Bayesian Models and Its Application to fMRI Data

Wentao Fan, Lin Yang, Nizar Bouguila

    IEEE Transactions on Neural Networks and Learning Systems
    |September 29, 2022
    PubMed
    Summary

    We introduce a novel hierarchical Bayesian model for analyzing spherical data, utilizing von Mises-Fisher distributions. This advanced method effectively models grouped data, showing promise in applications like fMRI analysis.

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    Area of Science:

    • Computational Statistics
    • Machine Learning
    • Bioinformatics

    Background:

    • Spherical data modeling is crucial for applications like gene expression analysis, document categorization, and gesture recognition.
    • Existing methods may not adequately capture the complex structures within grouped spherical datasets.

    Purpose of the Study:

    • To propose a novel hierarchical nonparametric Bayesian model for modeling grouped spherical data.
    • To utilize von Mises-Fisher (VMF) distributions within a hierarchical Pitman-Yor (HPY) process mixture model framework.

    Main Methods:

    • Developed a hierarchical nonparametric Bayesian model using von Mises-Fisher distributions.
    • Employed the hierarchical Pitman-Yor (HPY) process mixture model for infinite shared components.
    • Utilized a closed-form optimization algorithm based on variational Bayes (VB) for model learning.

    Main Results:

    • The proposed model effectively handles grouped spherical data with complex distributions.
    • Demonstrated the model's performance on both synthetic datasets and real-world resting-state fMRI data.
    • The hierarchical structure and VMF distributions capture heavy tails and skewness inherent in the data.

    Conclusions:

    • The developed hierarchical Bayesian nonparametric model offers a powerful approach for grouped spherical data analysis.
    • The model shows significant potential for applications in bioinformatics and neuroimaging, such as fMRI data analysis.