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Antimalarial treatment in infants.

Laura C Kalkman1, Thomas Hanscheid2, Sanjeev Krishna3,4,5

  • 1Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Amsterdam University Medical Centers, location Amsterdam, Amsterdam Infection & Immunity, Amsterdam Public Health, University of Amsterdam, Amsterdam, The Netherlands.

Expert Opinion on Pharmacotherapy
|September 29, 2022
PubMed
Summary

Infants with malaria require tailored treatment due to unique physiological changes affecting drug response. Current guidelines often overlook this group, increasing risks of treatment failure and toxicity.

Keywords:
Malariainfantspharmacodynamicspharmacokineticstreatment

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Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology
  • Global Health

Background:

  • Malaria is prevalent in infants in high-transmission areas, particularly those over six months old.
  • Infants experience physiological changes that alter drug pharmacokinetics and pharmacodynamics, impacting malaria treatment safety and efficacy.
  • Existing malaria treatment guidelines and research frequently do not adequately address the specific needs of infants.

Conclusions:

  • Further research, including dedicated infant trials and separate reporting of infant outcomes, is crucial.
  • Additional data on the efficacy, safety, tolerability, and effectiveness of Artemisinin-based Combination Therapies (ACTs) in infants is needed.
  • Population pharmacokinetic studies are essential to refine anti-malarial dosing and treatment regimens for infants.