Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

1.4K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
1.4K
Overview of Exosomes01:36

Overview of Exosomes

2.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.8K
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

7.0K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
7.0K
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

8.6K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-inflammatory and antinociceptive effects of a novel 1,5-benzodiazepine derivative in murine models.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

Discovery and therapeutic delivery of microRNAs targeting deregulated glioblastoma pathways inhibits tumor growth in mice.

The Journal of clinical investigation·2026
Same author

Second primary driver-negative lung adenocarcinoma following breast cancer treatment: a case report.

The Pan African medical journal·2026
Same author

Benzodiazepines for anxiety and depression: an updated overview of current use and major outcomes.

Molecular biology reports·2026
Same author

Nicotiana tabacum: From a Beneficial Plant to Harmful Products-A Comprehensive Review of Smokeless Tobacco and Its Adverse Health Effects.

TheScientificWorldJournal·2026
Same author

Differential regulation of immunoglobulin class switch recombination by the tumor suppressor p53.

Scientific reports·2026

Related Experiment Video

Updated: Aug 27, 2025

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

698

The Pathophysiological Role of Platelet-Derived Extracellular Vesicles.

Meryem Mabrouk1,2, Fadila Guessous3, Abdallah Naya2

  • 1Department of Biology, Faculty of Sciences, Mohammed V University in Rabat, Rabat, Morocco.

Seminars in Thrombosis and Hemostasis
|September 29, 2022
PubMed
Summary

Platelet-derived extracellular vesicles are tiny sacs released by activated platelets. These vesicles can travel to places platelets cannot, transferring vital contents and influencing various bodily functions.

More Related Videos

Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

16.0K
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

832

Related Experiment Videos

Last Updated: Aug 27, 2025

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

698
Routine Screening Method for Microparticles in Platelet Transfusions
09:49

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

16.0K
Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

832

Area of Science:

  • Hematology
  • Cell Biology
  • Immunology

Background:

  • Platelets are crucial for hemostasis, inflammation, and immunity.
  • Activated platelets release effector molecules and extracellular vesicles.
  • Platelet-derived extracellular vesicles (EVs) are submicron vesicles carrying platelet contents.

Approach:

  • This review synthesizes current knowledge on platelet-derived EVs.
  • It examines the formation and cargo of these vesicles.
  • The review discusses their unique ability to traverse biological barriers.

Key Points:

  • Platelet-derived EVs can enter lymph, bone marrow, and synovial fluid.
  • They transfer diverse molecular cargo, including nucleic acids and proteins.
  • These EVs mediate functions in locations inaccessible to parent platelets.

Conclusions:

  • Platelet-derived EVs play significant roles in physiological processes.
  • Their functions are critical in various pathophysiological conditions.
  • Understanding platelet-derived EVs is vital for medical research.