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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Related Experiment Video

Updated: Aug 27, 2025

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

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Histiocytic and dendritic cell neoplasms.

Stefano A Pileri1, Federica Melle, Giovanna Motta

  • 1Division of Hematopathology, European Institute of Oncology IRCCS, Via Ripamonti 435, Milan, Italy. stefano.pileri@unibo.it.

Pathologie (Heidelberg, Germany)
|September 29, 2022
PubMed
Summary

Histiocytic and dendritic cell neoplasms (HDCNs) are rare tumors. This review summarizes their characteristics, highlighting the need for an international registry to improve understanding and treatment of these orphan diseases.

Keywords:
Dendritic cell neoplasms of mesenchymal derivationDendritic cell neoplasms of myeloid derivationFollicular dendritic cell sarcomaHistiocytic sarcomaLangerhans cell tumors

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Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes
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Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

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Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
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Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes
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Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

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Area of Science:

  • Oncology
  • Pathology
  • Hematology

Background:

  • Histiocytic and dendritic cell neoplasms (HDCNs) are rare tumors with evolving classifications.
  • Recent years have seen significant debate and research into these uncommon malignancies.

Purpose of the Study:

  • To provide a comprehensive review of histiocytic and dendritic cell neoplasms.
  • To consolidate current knowledge on the diverse entities within HDCNs.

Main Methods:

  • Summarization of author experience from international studies and national reference centers.
  • In-depth discussion of clinical, morphologic, phenotypic, and molecular data for each HDCN entity.

Main Results:

  • Detailed characterization of various histiocytic and dendritic cell neoplasms.
  • Extensive review of the clinical, morphologic, phenotypic, and molecular profiles of HDCNs.

Conclusions:

  • HDCNs are classified as orphan diseases with a lack of standardized therapies.
  • An international registry is proposed to enhance knowledge dissemination and therapeutic strategies for HDCNs.