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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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TNFR2 antagonist and agonist: a potential therapeutics in cancer immunotherapy

Sameer Quazi1,2,3

  • 1GenLab Biosolutions Private Limited, Bangalore, 560043, Karnataka, India. Colonel.quazi@gmail.com.

Medical Oncology (Northwood, London, England)
|September 29, 2022
PubMed

Insights

Tumour necrosis factor receptor 2 (TNFR2) is a key target for cancer therapy, found on immunosuppressive cells. TNFR2 antagonists and agonists show promise in treating cancers and autoimmune disorders.

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • Tumour necrosis factor receptor 2 (TNFR2) is expressed on immunosuppressive cells like regulatory T cells (TREGs) and myeloid-derived suppressor cells (MDSCs).
  • TNFR2 plays a crucial role in the proliferation and function of TREGs and MDSCs, making it a significant target in cancer and autoimmune diseases.
  • Targeting TNFR2 offers a strategy to modulate immune responses in malignancies and autoimmune disorders.

Purpose of the Study:

  • To review the role of TNFR2 in cancer and autoimmune diseases.
  • To explore TNFR2 as a therapeutic target for malignancies.
  • To elucidate clinically administered TNFR2 antagonists and agonists in cancer treatment.

Main Methods:

  • Literature review of studies on TNFR2 expression and function.
  • Analysis of TNFR2's role in TREGs and MDSCs.
  • Examination of TNFR2 antagonists and agonists in preclinical and clinical settings.

Main Results:

  • TNFR2 is highly expressed on immunosuppressive TREGs and MDSCs, crucial for their activity.
  • TNFR2 modulation is vital for treating cancers and autoimmune disorders.
  • Development of TNFR2 antagonists and agonists has shown success in inhibiting TREG proliferation and enhancing T effector cells.

Conclusions:

  • TNFR2 is a promising therapeutic target for cancer treatment.
  • Structure-guided drug development for TNFR2 holds potential for novel cancer therapies.
  • TNFR2 antagonists and agonists are being investigated for clinical application in treating cancers.
Keywords:
AgonistAntagonistCD + Foxp3 +MDSCsTREG

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