Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genomic Characterization of Classic Adamantinoma, Osteofibrous Dysplasia, and Osteofibrous Dysplasia-like Adamantinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2026

Same author

Whose Role Is It, Anyway? Ensuring Correct Genomic Variant Nomenclature in Published Literature.

Clinical chemistry·2026

Same author

Experiences With Detection of Higher-Copy Sex Chromosome Aneuploidy by cfDNA Screening: The Critical Role of Diagnostic Testing.

American journal of medical genetics. Part A·2026

Same author

Brief Report: Androgen Receptor Expression Is Associated With Male Predominance in Thymic Neuroendocrine Neoplasms.

JTO clinical and research reports·2026

Same author

Increased SOX10, p16, and Cyclin D1 Immunoreactivity Differentiates MAP Kinase-activated Low-grade Gliomas From Piloid Gliosis: Erratum.

The American journal of surgical pathology·2025

Same author

Addressing Patient-Provider Communication Gaps in Vanishing Twin Syndrome: Implications for Patient Care and Clinical Guidelines.

Healthcare (Basel, Switzerland)·2025

Search research articles

Related Experiment Video

Updated: Aug 27, 2025

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Chromosomal microarray analysis in pregnancy loss: Is it time for a consensus approach?

Samantha L P Schilit^1,2, Courtney Studwell¹, Pamela Flatley¹

¹Division of Clinical Cytogenetics, Center for Advanced Molecular Diagnostics, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Prenatal Diagnosis

|September 30, 2022

Summary

Chromosomal microarray (CMA) effectively detects genetic abnormalities in products of conception (POC), outperforming karyotyping. This method aids in identifying recurrence risks for couples experiencing pregnancy loss.

More Related Videos

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Related Experiment Videos

Last Updated: Aug 27, 2025

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

Published on: October 20, 2019

FISH for Pre-implantation Genetic Diagnosis

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

Area of Science:

Genetics
Reproductive Medicine
Cytogenomics

Background:

Recurrent pregnancy loss necessitates accurate etiological investigation.
Cytogenomic analysis of products of conception (POC) is crucial for understanding miscarriage causes.

Purpose of the Study:

To evaluate the effectiveness and outcomes of chromosomal microarray (CMA) for cytogenomic analysis of POC.
To compare CMA with traditional karyotyping methods in POC evaluation.

Main Methods:

A 42-month retrospective study analyzed 323 POC samples using CMA.
Results were correlated with gestational age, phenotype, orthogonal testing, and parental analysis.

Main Results:

CMA identified abnormalities in 47.4% of first-trimester and 10.9% of later-trimester losses.
Discordance with karyotype was observed in 20% of cases, often due to maternal cell overgrowth.
Autosomal trisomies and triploidy were the most frequent abnormalities.

Conclusions:

CMA is a reliable method for POC genetic testing, aligning with karyotype study data.
CMA offers advantages over karyotyping by not requiring viable cultures.
CMA findings can identify increased recurrence risks for couples with pregnancy loss.