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Updated: Aug 27, 2025

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
Published on: January 25, 2017
Interleukin 22 and its association with neurodegenerative disease activity
Wenjian Chen1, Jianpeng Wang2, Huaizhi Yang2
1Department of Orthopaedics, Anhui Provincial Children's Hospital, Hefei, China.
Abstract:
It is worth noting that neuroinflammation is well recognized as a symptom of neurodegenerative diseases (NDs). The regulation of neuroinflammation becomes an attractive focus for innovative ND treatment technologies. There is evidence that IL-22 is associated with the development and progression of a wide assortment of NDs. For example, IL-22 can activate glial cells, causing them to generate pro-inflammatory cytokines and encourage lymphocyte infiltration in the brain. IL-22 mRNA is highly expressed in Alzheimer's disease (AD) patients, and a high expression of IL-22 has also been detected in the brains of patients with other NDs. We examine the role of IL-22 in the development and treatment of NDs in this review, and we believe that IL-22 has therapeutic potential in these diseases.
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