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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Nanocomposite hydrogels for biomedical applications.

Shanghui Huang1, Xiangqian Hong2,3, Mingyi Zhao4

  • 1Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering Jinan University Guangzhou China.

Bioengineering & Translational Medicine
|September 30, 2022
PubMed
Summary
This summary is machine-generated.

Nanomaterials offer unique properties for nanomedicine but have limitations. Combining them with hydrogels creates nanocomposite hydrogels, overcoming individual drawbacks for advanced biomedical applications.

Keywords:
bioimagingbiosensingcancer treatmentdrug and cell deliverynanocomposite hydrogelstissue regeneration

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Nanomaterials possess unique properties for nanomedicine but suffer from burst release, rapid elimination, and poor bioadhesion.
  • Hydrogels offer biocompatibility and drug delivery capabilities but have limitations in anti-tumor efficacy, bioimaging, and responsiveness.
  • Integrating nanomaterials into hydrogel networks can synergistically combine their strengths and mitigate individual weaknesses.

Purpose of the Study:

  • To review recent advances in nanomaterial-hydrogel composites for biomedical applications.
  • To discuss the development and potential of nanocomposite hydrogels in medicine.

Main Methods:

  • Comprehensive literature review of nanomaterial-hydrogel composite systems.
  • Analysis of physical and chemical integration methods of nanomaterials within hydrogel matrices.
  • Evaluation of functional properties imparted by nanomaterials (e.g., photo-thermal, targeting) and hydrogels (e.g., plasticity, retention).

Main Results:

  • Nanocomposite hydrogels leverage nanomaterials as functional cores, enhancing properties like photo-thermal conversion, magnetothermal conversion, conductivity, and tumor targeting.
  • Hydrogels improve nanomaterial retention and plasticity, enabling diverse applications such as biosensors.
  • These systems show significant promise in drug and cell delivery, cancer treatment, tissue regeneration, biosensing, and bioimaging.

Conclusions:

  • Nanocomposite hydrogels represent a powerful strategy to overcome the limitations of individual nanomaterials and hydrogels in nanomedicine.
  • These advanced materials offer broad prospects for various biomedical applications, with ongoing efforts towards their commercialization.