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Multimodal 3D Printing of Phantoms to Simulate Biological Tissue
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An anatomically correct 3D-printed mouse phantom for magnetic particle imaging studies.

Nicole S Sarna1, Leyda Marrero-Morales1, Ryan DeGroff1

  • 1J. Crayton Pruitt Family Department of Biomedical Engineering University of Florida Gainesville Florida USA.

Bioengineering & Translational Medicine
|September 30, 2022
PubMed
Summary

We developed 3D-printed mouse phantoms for magnetic particle imaging (MPI) experiments. These phantoms enable accurate tracer quantification and improve the planning of in vivo studies by simulating realistic anatomical conditions.

Keywords:
3D printinganimal replacementimaging phantommagnetic particle imaging

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Area of Science:

  • Biomedical Imaging
  • Medical Physics
  • 3D Printing Technology

Background:

  • Magnetic Particle Imaging (MPI) is an emerging technology for in vivo imaging.
  • Accurate quantification of MPI tracer distribution is crucial for diagnostic and therapeutic applications.
  • Standardized phantoms are needed to validate MPI analysis protocols and experimental designs.

Purpose of the Study:

  • To create anatomically correct 3D-printed mouse phantoms for Magnetic Particle Imaging (MPI) studies.
  • To evaluate the accuracy of tracer mass quantification using these phantoms.
  • To assess the impact of tracer distribution on MPI sensitivity and detection limits.

Main Methods:

  • Utilized the Digimouse 3D whole body mouse atlas to design phantoms with realistic organ cavities (liver, brain tumor, breast tumor).
  • Acquired MPI scans in various modes (2D, 3D, high sensitivity, HSHR) using a MOMENTUM imager.
  • Employed a thresholding algorithm and known mass fiducials for quantitative tracer mass estimation within defined regions of interest (ROIs).

Main Results:

  • Demonstrated accurate estimation of tracer mass in simulated liver and tumor regions.
  • Showed that tracer distribution significantly affects the limit of detection in MPI.
  • Observed reduced sensitivity in tumor regions when higher tracer masses were present in the liver cavity.

Conclusions:

  • 3D-printed anatomically correct mouse phantoms are valuable tools for planning MPI experiments.
  • These phantoms facilitate the evaluation and optimization of MPI data analysis methods.
  • The study highlights the sensitivity of MPI detection limits to tracer distribution patterns.