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Updated: Aug 27, 2025
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
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Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy
Su Zhang1, Yang Meng1, Lian Zhou1
1Laboratory of Cancer Epigenetics and Genomics Frontiers Science Center for Disease-Related Molecular Network State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China.
Medcomm
|September 30, 2022
Summary
Understanding epigenetic regulators is key to resolving chronic inflammation. Targeting these mechanisms offers potential for treating inflammatory diseases and improving outcomes.
Area of Science:
- Immunology
- Epigenetics
- Molecular Biology
Background:
- Inflammation resolution is a crucial endogenous process.
- Chronic inflammatory diseases involve dysregulated immune responses and excessive tissue inflammation.
- Epigenetic alterations, including DNA methylation and histone modifications, are implicated in inflammatory disorders.
Purpose of the Study:
- To elucidate the role of key signaling pathways (NF-κB, JAK/STAT) and NLRP3 inflammasome in chronic inflammation.
- To explore the relationship between inflammation, COVID-19, and cancer.
- To review epigenetic modifications in inflammation and innate immunity and discuss therapeutic potential.
Main Methods:
- Review of existing literature on inflammation, epigenetics, and related signaling pathways.
- Analysis of the interplay between inflammatory responses and epigenetic modifications.
- Discussion of therapeutic strategies targeting epigenetic regulators.
Main Results:
- The nuclear factor-κB signaling pathway, JAK/STAT signaling pathway, and NLRP3 inflammasome are critical in chronic inflammatory diseases.
- Inflammation can trigger epigenetic alterations, which in turn mediate inflammatory actions.
- A complex relationship exists between inflammation, COVID-19, and human cancers.
Conclusions:
- Targeting epigenetic regulators offers a promising therapeutic avenue for chronic inflammation-associated diseases.
- Understanding the molecular mechanisms of epigenetic regulation in inflammation is essential for developing effective treatments.
- Interventions targeting epigenetic mechanisms hold potential for improving therapeutic outcomes in inflammatory conditions.
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