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Microvesicles: the functional mediators in sorafenib resistance

Cong He1,2, Doulathunnisa Jaffar Ali1, Bo Sun1

  • 1State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, Jiangsu, China.

Cancer Drug Resistance (Alhambra, Calif.)
|September 30, 2022
PubMed

Insights

Microvesicles (MVs) are key in liver cancer drug resistance, transferring molecules that cause resistance. However, these MVs can also deliver therapies to reverse resistance, offering new treatment strategies.

Area of Science:

  • Oncology
  • Cell Biology
  • Biochemistry

Background:

  • Drug resistance is a major challenge in cancer therapy.
  • The tumor microenvironment significantly influences treatment efficacy.
  • Microvesicles (MVs) mediate intercellular communication and impact tumor progression.

Purpose of the Study:

  • To review the role of MVs in liver cancer progression and treatment.
  • To explore mechanisms of sorafenib resistance in hepatocellular carcinoma.
  • To highlight the potential of MVs in overcoming drug resistance.

Main Methods:

  • Literature review of studies on microvesicles and liver cancer.
  • Analysis of mechanisms underlying sorafenib resistance.
  • Evaluation of MVs as therapeutic carriers.

Main Results:

  • MVs contribute to drug resistance by transferring functional molecules.
  • MVs can be engineered as drug delivery systems to reverse resistance.
  • Understanding MV function offers insights into novel therapeutic approaches.

Conclusions:

  • Microvesicles play a dual role in liver cancer, promoting resistance and offering therapeutic potential.
  • Targeting MVs could be a strategy to overcome sorafenib resistance in hepatocellular carcinoma.
  • Further research into MVs may lead to precise, novel cancer therapeutics.
Keywords:
Microvesicles (MVs)cancer therapysorafenib resistancetumor microenvironment

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