Related Experiment Video

Updated: Aug 27, 2025

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

33.7K

DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology

Hao Xiong1,2, Fuzhou Hua1,2, Yao Dong3

  • 1Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Frontiers in Aging Neuroscience
|September 30, 2022
PubMed

Insights

Cellular senescence drives aging. This review explores how GATA4 influences DNA damage response and senescence, impacting age-related diseases like heart failure.

Area of Science:

  • Molecular Biology
  • Gerontology
  • Cell Biology

Background:

  • Cellular senescence, a key driver of aging, involves the DNA damage response (DDR).
  • The DDR pathway activates kinases like ATM and ATR, leading to p53-mediated cell cycle arrest and senescence.
  • GATA4, a crucial transcription factor in organ development, is increasingly implicated in aging processes.

Purpose of the Study:

  • To review the intricate relationship between GATA4, DNA damage response (DDR), and cellular senescence.
  • To elucidate GATA4's role in the aging process.
  • To examine the association between the GATA4 signaling pathway and aging-related pathologies.

Main Methods:

  • Literature review of studies on GATA4, DDR, cellular senescence, and aging.
  • Analysis of existing research linking GATA4 to biological aging mechanisms.
  • Synthesis of evidence on GATA4's involvement in age-related diseases.

Main Results:

  • GATA4 contributes to the DDR, thereby influencing cellular senescence and aging.
  • The GATA4 signaling pathway is implicated in the pathogenesis of aging-related conditions.
  • Evidence suggests GATA4 plays a significant role in the progression of aging.

Conclusions:

  • GATA4 is a critical factor linking DDR, cellular senescence, and organismal aging.
  • Targeting the GATA4 pathway may offer therapeutic strategies for age-related diseases.
  • Further research into GATA4's function is essential for understanding and combating aging.
Keywords:
CGATA4DNA damage responseatherosclerosiscellular senescenceheart failure

More Related Videos

Induction and Validation of Cellular Senescence in Primary Human Cells08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.1K
SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.2K

Related Concept Videos

DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.3K
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
31.4K
DNA Damage Can Stall the Cell Cycle02:37

DNA Damage Can Stall the Cell Cycle

2.7K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.7K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
6.7K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.3K