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Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...

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Related Experiment Video

Updated: Aug 27, 2025

Isolating Intestinal Stem Cells from Adult Drosophila Midguts by FACS to Study Stem Cell Behavior During Aging

Isolating Intestinal Stem Cells from Adult Drosophila Midguts by FACS to Study Stem Cell Behavior During Aging

Published on: December 16, 2014

Tiny Drosophila intestinal stem cells, big power.

Jingbo Zhai^1,2,3, Wanyang Li¹, Xin Liu^1,2,3

¹Medical College, Inner Mongolia Minzu University, Tongliao, China.

Cell Biology International

|September 30, 2022

Summary

This summary is machine-generated.

Fruit fly intestines offer a powerful model for studying human gut development and disease. Researchers use Drosophila to explore stem cell niches, asymmetric division, environmental interactions, and screen for aging and cancer factors.

Keywords:

Drosophila microbiota midgut signaling crosstalk stem cells

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Area of Science:

Developmental Biology
Gastroenterology
Comparative Biology

Background:

Signaling pathways in intestinal development, regeneration, and disease are conserved between Drosophila and mammals.
Drosophila provides powerful genetic tools for biological research, serving as a model for mammalian systems.

Purpose of the Study:

To review recent advances in using the fly midgut to address key questions in intestinal biology.
To highlight Drosophila as a model for understanding stem cell niches, asymmetric division, environmental interactions, and disease screening.

Main Methods:

Utilizing Drosophila melanogaster as a model organism.
Leveraging powerful genetic tools available in Drosophila.
Analyzing conserved signaling pathways in the fly midgut.

Main Results:

The fly midgut model facilitates the study of intestine stem cell niche establishment.
Factors controlling asymmetric stem cell division can be elucidated using Drosophila.
Interactions between intestinal cells and environmental factors like damage, microbiota, and diet are investigable.
The fly intestine is a viable system for screening aging/cancer-related factors and drugs.

Conclusions:

Drosophila melanogaster is a valuable model for fundamental biological questions in intestinal development, regeneration, and disease.
The fly midgut provides a powerful platform for advancing our understanding of gut health and disease mechanisms.