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Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
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Hypertrophic cardiomyopathy with heart failure and ST-segment elevation of the lateral wall

Lin Bai1, Yali Wang1, Fei Chen1

  • 1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.

ESC Heart Failure
|September 30, 2022
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease. This case highlights an atypical presentation of HCM, emphasizing the need for comprehensive diagnostics beyond typical symptoms.

Area of Science:

  • Cardiovascular Medicine
  • Genetics
  • Medical Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiovascular disease, typically caused by single-gene mutations.
  • Clinical presentations of HCM vary widely, from asymptomatic carriers to severe left ventricular outflow tract obstruction and end-stage disease.

Keywords:
Cardiac magnetic resonanceGenetic testHeart failureHypertrophic cardiomyopathyST-segment elevation

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