Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative results of pulmonary vein isolation in atrial fibrillation patients undergoing off-pump <i>vs</i>. on-pump beating-heart coronary artery bypass grafting: a retrospective cohort study.

Cardiovascular diagnosis and therapy·2026
Same author

Left-Handed Cardiac Surgery Learning Lab: An EACTS Annual Meeting Initiative.

Interdisciplinary cardiovascular and thoracic surgery·2025
Same author

Effect of aerobic exercise on the susceptibility of atrial fibrillation among aged mice.

Journal of thoracic disease·2025
Same author

Minimally Invasive Off-Pump Coronary Artery Bypass as Palliative Revascularization in High-Risk Patients.

Clinics and practice·2025
Same author

Minimally Invasive Mitral Valve Surgery Using the FlexCrown Retractor: A Safe and Effective New Self-Expandable Left Atrial Exposure Device.

Innovations (Philadelphia, Pa.)·2025
Same author

Medium- and Long-Term Outcomes of 597 Patients Following Minimally Invasive Multi-Vessel Coronary Off-Pump Bypass Surgery.

Journal of clinical medicine·2025
Same journal

[Extrasystoles in endurance athletes].

Herzschrittmachertherapie & Elektrophysiologie·2026
Same journal

[AI-Assisted ECG diagnostics : Classical test statistics still apply].

Herzschrittmachertherapie & Elektrophysiologie·2026
Same journal

[Perioperative complications during transvenous pacemaker and defibrillator implantation].

Herzschrittmachertherapie & Elektrophysiologie·2026
Same journal

Herzschrittmachertherapie & Elektrophysiologie·2026
Same journal

[Late complications after atrial fibrillation ablation : Diagnosis and management].

Herzschrittmachertherapie & Elektrophysiologie·2026
Same journal

[Position paper of the German Society of Cardiology-quality criteria for performing catheter ablation of atrial fibrillation: executive summary].

Herzschrittmachertherapie & Elektrophysiologie·2026
See all related articles

Related Experiment Video

Updated: Aug 27, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.5K

Surgical atrial appendage closure: time for a randomized study.

Magdalena Rufa1, Nora Göbel2, Ulrich F W Franke2

  • 1Department of Cardiovascular Surgery, Robert Bosch Hospital Stuttgart, Auerbachstraße 110, 70376, Stuttgart, Germany. Magdalena.Rufa@rbk.de.

Herzschrittmachertherapie & Elektrophysiologie
|September 30, 2022
PubMed
Summary
This summary is machine-generated.

Surgical left atrial appendage occlusion effectively prevents stroke in atrial fibrillation patients, offering an alternative to anticoagulants. This review explores its safety, efficacy, and impact on oral anticoagulation post-procedure.

Keywords:
Anticoagulation therapyAtrial fibrillationCardiac surgeryLeft atrial appendageOcclusion

More Related Videos

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

83.8K
Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

3.8K

Related Experiment Videos

Last Updated: Aug 27, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.5K
The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

83.8K
Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

3.8K

Area of Science:

  • Cardiology
  • Vascular Surgery
  • Thrombosis Research

Background:

  • Atrial fibrillation (AF) affects over 30 million globally, with the left atrial appendage (LAA) being a primary source of thrombus formation.
  • Oral anticoagulants are standard for stroke prevention in AF but face challenges like bleeding risks and noncompliance.
  • Surgical LAA occlusion is an emerging alternative, potentially reducing thromboembolism but carrying procedural risks.

Purpose of the Study:

  • To review observational studies on LAA occlusion's impact on stroke.
  • To discuss the LAAOS III trial's findings on surgical LAA occlusion for ischemic stroke prevention.
  • To evaluate the safety and effectiveness of surgical LAA occlusion methods and the potential cessation of oral anticoagulation.

Main Methods:

  • Review of observational studies investigating LAA occlusion and stroke risk.
  • Analysis of data from the LAAOS III (Left Atrial Appendage Occlusion Study) trial.
  • Assessment of surgical techniques for LAA occlusion and their clinical outcomes.

Main Results:

  • The LAAOS III trial provided definitive evidence supporting surgical LAA occlusion for reducing ischemic stroke.
  • Various surgical methods for LAA occlusion have been examined for safety and efficacy.
  • The review addresses the question of whether oral anticoagulation can be discontinued after LAA occlusion.

Conclusions:

  • Surgical LAA occlusion is a viable strategy for stroke prevention in AF patients, particularly when anticoagulation is contraindicated or poorly tolerated.
  • Further research is needed to optimize surgical techniques and establish definitive guidelines for post-procedure anticoagulation management.
  • LAA occlusion represents a significant advancement in managing thromboembolic risk associated with atrial fibrillation.