Related Experiment Video

Updated: Aug 27, 2025

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy
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Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy

Published on: April 21, 2023

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Role of Pyruvate Kinase M2 (PKM2) in Cardiovascular Diseases

Mohd Rihan1, Shyam Sunder Sharma2

  • 1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar, Punjab, India.

Journal of Cardiovascular Translational Research
|September 30, 2022
PubMed

Insights

Pyruvate kinase M2 (PKM2) and its modulators show promise for treating cardiovascular diseases (CVDs). Targeting PKM2 offers a potential new therapeutic strategy to overcome limitations of current CVD treatments.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) are the leading global cause of death, with existing treatments having significant limitations.
  • Current pharmacological therapies for CVDs often exhibit time-dependency, hypotension, and bradycardia, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To explore the role of pyruvate kinase M2 (PKM2) in cardiovascular diseases.
  • To investigate the therapeutic potential of PKM2 modulators (inhibitors and activators) for CVDs.

Main Methods:

  • Review of recent scientific literature on PKM2 function and its relevance to cardiovascular pathophysiology.
  • Analysis of studies investigating PKM2 modulators in the context of various cardiovascular conditions.

Main Results:

  • PKM2 plays a role in key cellular processes including apoptosis, mitosis, hypoxia, inflammation, and metabolic reprogramming, all relevant to CVDs.
  • Modulation of PKM2 activity has demonstrated promising outcomes in preclinical models of cardiovascular diseases.

Conclusions:

  • PKM2 is implicated in the pathogenesis of various cardiovascular diseases.
  • Targeting PKM2 with specific modulators presents a promising therapeutic avenue for improving CVD treatment strategies.
Keywords:
Cardiovascular diseaseHeartPKPKM1PKM2

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