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Outcomes of children with idiopathic steroid resistant nephrotic syndrome: a single centre observational study

Om P Mishra1, Minketan Sidar1, Vineeta V Batra2

  • 1Banaras Hindu University, Institute of Medical Sciences, Department of Pediatrics, Division of Pediatric Nephrology, Varanasi, India.

Jornal Brasileiro De Nefrologia
|September 30, 2022
PubMed

Insights

Half of children with idiopathic steroid resistant nephrotic syndrome (SRNS) achieved remission. Factors like age, medication, and histology did not impact remission or kidney function survival in this 5-year study.

Area of Science:

  • Pediatric Nephrology
  • Immunology
  • Clinical Medicine

Background:

  • Idiopathic steroid-resistant nephrotic syndrome (SRNS) presents variable outcomes in pediatric populations.
  • Understanding factors influencing remission and kidney function is crucial for managing SRNS.

Purpose of the Study:

  • To determine the cumulative remission rate in children with SRNS.
  • To identify factors affecting remission status, kidney function survival, and medication side effects.

Main Methods:

  • A cohort of 114 pediatric patients with SRNS was analyzed over a 5-year follow-up period.
  • Treatment involved a calcineurin inhibitor-based protocol, prednisolone, and angiotensin-converting enzyme inhibitors.
  • Data collected included age of onset, eGFRcr, histopathology, and adverse events.

Main Results:

  • 57.3% of patients achieved remission (30% complete, 27.3% partial).
  • Kidney function survival was 87.3%, with 12.7% progressing to chronic kidney disease (CKD).
  • Age of onset, calcineurin inhibitor use, and histopathology did not significantly influence remission or kidney function survival.

Conclusions:

  • Approximately half of pediatric SRNS patients achieved remission.
  • Early disease onset, specific medications (cyclosporine/tacrolimus), and histopathology did not predict remission or short-term kidney function outcomes.
  • Further research may explore other therapeutic targets for SRNS.
Abstract

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