UP165, A Standardized Corn Leaf Extract for Improving Sleep Quality and Mood State

Area of Science:

• Nutritional Science
• Sleep Medicine
• Psychology

Background:

• Sleep quality and overall well-being are crucial for daily functioning.
• Stress and mood disturbances can negatively impact sleep and quality of life.
• Standardized botanical extracts are increasingly explored for their health benefits.

Purpose of the Study:

• To evaluate the efficacy of UP165, a standardized Zea mays (corn) leaf extract, on sleep quality and well-being.
• To assess the impact of UP165 on stress levels (salivary cortisol) and mood states (POMS).
• To determine dose-dependent effects of UP165 on sleep parameters and psychological well-being.

Main Methods:

• A double-blind, placebo-controlled clinical trial involving 45 participants aged 19-73.
• Oral administration of UP165 (250 and 500 mg/day) or placebo for 4 weeks, taken ~60 minutes before bedtime.
• Objective and subjective measures including fitness trackers, Pittsburgh Sleep Quality Index (PSQI), salivary cortisol, and Profile of Mood States (POMS).

Main Results:

• UP165 demonstrated a statistically significant, dose-correlated reduction in salivary cortisol (up to 36%).
• Participants experienced increased deep sleep time (up to 30 min, 7x placebo effect) and total sleep time (up to 10%).
• Significant improvements were observed in sleep quality (up to 49%, 10x PSQI improvement vs. placebo) and POMS scores (36-58%).

Conclusions:

• UP165 is a safe nutritional supplement that clinically supports 24-hour well-being.
• The extract enhances sleep quality and efficiency at night.
• UP165 improves mood state and overall well-being during the day.