Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

1.6K
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
1.6K
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

2.1K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
2.1K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

1.2K
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1.2K
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

3.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
3.2K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

5.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
5.0K
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

77
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
77

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood Doping: An Update.

The Physician and sportsmedicine·2016
Same author

Sportsmedicine forum.

The Physician and sportsmedicine·2016
Same author

Effect of Perioperative β-Blockers on Pulmonary Complications among Patients with Chronic Obstructive Pulmonary Disease Undergoing Lung Resection Surgery.

Lung cancer international·2015
Same author

Viscoelastic response of the midpalatal suture during maxillary expansion treatment.

Orthodontics & craniofacial research·2015
Same author

The influence of a single dose of I-131 on the retention and distribution of I-131 in the rat.

UCRL [reports]. U.S. Atomic Energy Commission·2014
Same author

Evidence for an alternative route from sterol to sapogenin in suspension cultures from Trigonella foenumgraecum.

Plant cell reports·2013

Related Experiment Video

Updated: May 5, 2026

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
09:50

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Published on: February 12, 2015

11.3K

Response to corticosteroids in chronic bronchitis.

C Shim, D E Stover, M H Williams

    The Journal of Allergy and Clinical Immunology
    |December 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Sputum eosinophilia, not blood eosinophilia, predicts a positive response to corticosteroid therapy in chronic bronchitis patients. This finding helps identify individuals who will benefit from steroid treatment.

    More Related Videos

    Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
    08:17

    Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

    Published on: August 25, 2017

    10.7K
    Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
    02:34

    Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

    Published on: May 10, 2024

    2.3K

    Related Experiment Videos

    Last Updated: May 5, 2026

    Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
    09:50

    Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

    Published on: February 12, 2015

    11.3K
    Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
    08:17

    Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

    Published on: August 25, 2017

    10.7K
    Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
    02:34

    Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

    Published on: May 10, 2024

    2.3K

    Area of Science:

    • Pulmonology
    • Pharmacology

    Background:

    • Corticosteroids are frequently used for chronic bronchitis.
    • Patient characteristics predicting response to corticosteroids are unknown.

    Purpose of the Study:

    • To identify predictors of favorable corticosteroid response in chronic bronchitis.

    Main Methods:

    • Double-blind, placebo-controlled crossover study.
    • 24 chronic bronchitis patients received prednisone or placebo for one week.
    • Evaluated physical exams, symptoms, blood/sputum eosinophils, and spirometry (FVC, FEV1).

    Main Results:

    • Seven of 24 patients showed improved FEV1 with prednisone.
    • Elevated blood eosinophils (≥350/mm³) were present in 7 patients, with 2 improving.
    • Sputum eosinophilia predicted steroid response in 7 of 9 patients.

    Conclusions:

    • Sputum eosinophilia is a reliable predictor of corticosteroid responsiveness in chronic bronchitis.
    • Blood eosinophil counts do not reliably predict response.
    • This aids in personalized steroid treatment selection for chronic bronchitis.