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The role of cyclins in the development and progression of prostate cancer

Joanna Dulińska-Litewka1, Dominik Felkle1, Kacper Dykas1

  • 1Chair of Medical Biochemistry, Jagiellonian University Medical College, 31-034 Krakow, Mikołaja Kopernika Street 7C, Poland.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 30, 2022
PubMed

Insights

Cyclins play a key role in hormone-dependent cancers like prostate cancer, influencing cell cycle and signaling pathways. Understanding cyclin interactions with androgen signaling is vital for overcoming therapy resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Cyclins are critical in hormone-dependent neoplasms, particularly in therapy resistance observed in breast cancer.
  • Prostate cancer research has less extensively studied cyclins compared to breast cancer, with roles of cyclins D2, D3, E, and H requiring further investigation.
  • Cyclins regulate diverse cellular processes beyond the cell cycle and interact with signaling pathways like MAPK/ERK, PI3K/Akt, and Notch.

Purpose of the Study:

  • To summarize current knowledge on the influence of cyclins on prostate cancer progression.
  • To elucidate the interactions between androgen receptor signaling and cyclins in prostate cancer.
  • To explore mechanisms of therapy resistance involving cyclins in prostate cancer.

Main Methods:

  • Literature review of current research on cyclins in prostate cancer.
  • Analysis of molecular pathways involving cyclins and androgen signaling.
  • Examination of studies on cyclin cross-talk with other signaling pathways.

Main Results:

  • Cyclins A1 and D1 signaling pathways are described in prostate cancer.
  • The roles of cyclins D2, D3, E, and H in prostate cancer progression are under investigation.
  • Androgen signaling axis significantly interferes with cyclin pathways in prostate cancer.

Conclusions:

  • Cyclins are integral to prostate cancer progression and therapeutic resistance.
  • Further research into specific cyclins and their interactions is needed to develop novel therapies.
  • Targeting cyclin pathways presents a potential strategy to overcome resistance in prostate cancer treatment.
Keywords:
Androgen receptorAndrogensCyclinProstate

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