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Updated: Aug 27, 2025

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Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
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Nerve Decompression and Distal Transtibial Amputation
Edgardo R Rodriguez-Collazo1, Stephanie Oexeman2, Lauren L Schnack3
1Department of Surgery, Ascension Saint Joseph - Chicago, Laboure Outpatient Clinic, 2913 North Commonwealth Avenue, Chicago, IL 60657, USA.
Clinics in Podiatric Medicine and Surgery
|September 30, 2022
Abstract:
Approximately 20% of patients with diabetic peripheral neuropathy (DPN) endorse painful sensations such as prickling, stabbing, and burning pain that reflect small-fiber involvement. Although glycemic control is crucial to delay the onset and progression of DPN, there have been many reports on the use of decompression nerve surgery to aid in the treatment of DPN.

