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Updated: Aug 27, 2025

Transcriptome Analysis of Single Cells

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

The Pineal Transcriptome Webpage.

David C Klein¹, Steven L Coon²

¹Section on Neuroendocrinology, Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. kleind@mail.nih.gov.

Methods in Molecular Biology (Clifton, N.J.)

|September 30, 2022

Summary

This summary is machine-generated.

This study presents a new webpage detailing the pineal gland transcriptome across various vertebrates. It offers insights into gene expression, rhythmicity, and treatment effects, with all data freely accessible.

Keywords:

Chicken Database Day/night expression Human Mouse Multispecies Pineal Rat Retina Rhesus Transcriptome Webpage Zebrafish

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Area of Science:

Neuroscience
Genomics
Chronobiology

Background:

The pineal gland regulates circadian rhythms and produces melatonin.
Understanding pineal gland function requires detailed transcriptomic data.
Comparative transcriptomics can reveal evolutionary insights into visual and circadian systems.

Purpose of the Study:

To create a comprehensive, publicly accessible database of vertebrate pineal gland and retinal transcriptomes.
To enable the study of gene expression patterns and rhythmicity in these tissues.
To provide data on the impact of denervation and pharmacological treatments on rat pineal gene expression.

Main Methods:

Development of a dedicated webpage for data dissemination.
Collection and analysis of transcriptomic data from multiple vertebrate species (human, rhesus, rat, mouse, chicken, zebrafish).
Inclusion of data from day/night experiments and specific rat treatment studies.

Main Results:

A curated dataset of transcript expression profiles for the vertebrate pineal gland and retina is now available.
The data allows for the examination of daily rhythms in gene expression.
Information on surgical denervation and pharmacological treatments in rats is integrated.

Conclusions:

The pineal transcriptome webpage serves as a valuable resource for researchers studying circadian biology, neuroendocrinology, and comparative genomics.
The freely available data facilitates further investigation into the molecular mechanisms underlying pineal gland function.
This resource supports comparative analyses across species and experimental conditions.