Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Olfactory bulb changes in Alzheimer's disease.

T G Ohm, H Braak

    Acta Neuropathologica
    |January 1, 1987
    PubMed
    Summary

    Alzheimer's disease affects olfactory bulbs, with pathological filaments found in specific neurons. These findings in Alzheimer's disease (AD) patients offer insights into olfactory bulb pathology.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Review: Sporadic Parkinson's disease: development and distribution of α-synuclein pathology.

    Neuropathology and applied neurobiology·2015
    Same author

    [Pathogenesis and prevention of Alzheimer's disease: when and in what way does the pathological process begin?].

    Der Nervenarzt·2013
    Same author

    [Pathophysiology of sporadic Parkinson's disease].

    Fortschritte der Neurologie-Psychiatrie·2010
    Same author

    [Transcraniel ultrasound in the differential diagnosis of Parkinson's disease].

    Fortschritte der Neurologie-Psychiatrie·2010
    Same author

    [A new look at the corticostriatal-thalamocortical circuit in sporadic Parkinson's disease].

    Der Nervenarzt·2008
    Same author

    Parkinson's disease: a dual-hit hypothesis.

    Neuropathology and applied neurobiology·2007

    Area of Science:

    • Neuroscience
    • Neuropathology
    • Alzheimer's Disease Research

    Background:

    • Alzheimer's disease (AD) is a neurodegenerative disorder.
    • Olfactory dysfunction is an early symptom in AD.
    • The pathological changes in the olfactory bulb in AD are not fully understood.

    Purpose of the Study:

    • To investigate the distribution and types of neuropathological changes in the olfactory bulbs of Alzheimer's disease patients.
    • To identify specific neuronal populations affected by neurofibrillary tangles and neuritic plaques in the olfactory bulb.

    Main Methods:

    • Combined silver staining for pathological filaments and Nissl staining for cell bodies.
    • Microscopic examination of olfactory bulb tissue from Alzheimer's disease cases and age-matched controls.

    Main Results:

    • Neuritic plaques were identified in the anterior olfactory nucleus.
    • Neurofibrillary tangles and neuropil threads were present in the anterior olfactory nucleus and olfactory bulb layers (excluding the outer fibrous layer).
    • Tangle-bearing neurons included tufted cells, outer granule cells, and specific nerve cells in the rostral anterior olfactory nucleus.

    Conclusions:

    • The olfactory bulb, particularly the anterior olfactory nucleus, exhibits significant Alzheimer's disease-related pathology.
    • Specific neuronal types within the olfactory bulb are vulnerable to neurofibrillary tangle formation in Alzheimer's disease.
    • These findings contribute to understanding the neuropathological basis of olfactory deficits in Alzheimer's disease.

    Related Experiment Videos