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Association between diabetes mellitus and post-stroke cognitive impairment
Kang-Po Lee1,2, Jung-Sheng Chen3, Chih-Yuan Wang4
1College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Journal of Diabetes Investigation
|October 1, 2022
Summary
Diabetes significantly impacts stroke survivors, worsening cognitive function. Managing blood sugar and exploring novel biomarkers like glycemic variability may help prevent post-stroke cognitive impairment and dementia.
Area of Science:
- Neurology
- Endocrinology
- Metabolic Syndrome
Background:
- Stroke survivors experience diverse impairments, influenced by factors like diabetes mellitus.
- Diabetes mellitus is linked to structural brain changes and post-stroke cognitive dysfunction.
Purpose of the Study:
- To review brain changes in stroke survivors with diabetes.
- To examine the relationship between glycemic control and post-stroke cognitive impairment (PSCI) and dementia (PSD).
- To identify novel biomarkers and modifying methods for glycemic control to prevent PSCI/PSD.
Main Methods:
- Literature review of structural and pathological brain changes in stroke survivors with diabetes.
- Analysis of evidence linking hyperglycemia, diabetes mellitus, and hypoglycemia to PSCI and PSD.
- Exploration of biomarkers including HbA1c, glycemic variability, receptor for advanced glycation end products, and gut microbiota.
Main Results:
- Diabetes mellitus contributes to structural and pathological brain changes, potentially causing cognitive dysfunction post-stroke.
- Hyperglycemia, diabetes, and hypoglycemia are associated with increased risk of PSCI and PSD.
- Novel biomarkers and glycemic control strategies show promise in predicting and preventing cognitive decline.
Conclusions:
- Glycemic control is crucial for stroke survivors with diabetes to mitigate cognitive impairments.
- Emerging biomarkers offer new avenues for predicting and managing post-stroke cognitive dysfunction.
- Targeted interventions focusing on blood sugar management are essential for preventing PSCI and PSD.
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