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C-reactive protein in acute otitis media.

P Karma, M Sipilä, M Koskela

    Acta Oto-Laryngologica
    |May 1, 1987
    PubMed
    Summary

    Serum C-reactive protein (CRP) levels in children with acute otitis media (AOM) were analyzed. Higher CRP indicated a greater likelihood of major pathogens like S. pneumoniae or H. influenzae, though clinical correlation was limited.

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    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Clinical Chemistry

    Background:

    • Acute otitis media (AOM) is a common childhood infection.
    • Biomarkers like C-reactive protein (CRP) can aid in diagnosis and management.
    • Understanding CRP levels in AOM is crucial for effective treatment strategies.

    Purpose of the Study:

    • To investigate the relationship between serum C-reactive protein (CRP) levels and the presence of pathogens in children with acute otitis media (AOM).
    • To explore potential correlations between CRP levels and clinical parameters in AOM.

    Main Methods:

    • Serum CRP levels were measured in 79 children diagnosed with AOM.
    • CRP levels were categorized (<10 mg/l, ≥20 mg/l, ≥40 mg/l).
    • Association between CRP levels and identified pathogens (S. pneumoniae, H. influenzae) was analyzed.

    Main Results:

    • Higher CRP levels (≥20 mg/l and ≥40 mg/l) were significantly more frequent in AOM cases caused by S. pneumoniae or H. influenzae compared to those without major pathogens (p<0.01 and p<0.001).
    • Statistically significant correlations between CRP and clinical parameters were infrequent, but a trend towards higher CRP with a more severe clinical picture was observed.
    • AOM cases with very high CRP (≥100 mg/l) were associated with bilateral infections, major pathogens, preceding respiratory infections, high fever, and significant middle ear effusion, but did not show different overall morbidity.

    Conclusions:

    • Serum CRP levels can be a useful indicator for the presence of major bacterial pathogens in acute otitis media.
    • While CRP correlates with severe clinical presentation, its direct correlation with specific clinical parameters in AOM is limited.
    • Elevated CRP in AOM warrants consideration of bacterial etiology, particularly in severe cases.

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