Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pigment anomaly-associated inner ear deafness.

A Schrott, H Spoendlin

    Acta Oto-Laryngologica
    |May 1, 1987
    PubMed
    Summary

    Pigment anomalies cause hereditary deafness by affecting neural crest-derived melanocytes. The absence of these melanocytes in the inner ear

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Normal saline versus a balanced crystalloid for goal-directed perioperative fluid therapy in major abdominal surgery: a double-blind randomised controlled study.

    British journal of anaesthesia·2018
    Same author

    Localization of chat-like immunoreactivity in the vestibular endorgans of the rat.

    Hearing research·1994
    Same author

    A quantitative study of nerve fibers in the human facial nerve.

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·1993
    Same author

    [Trans-septo-sphenoidal operation for pituitary adenoma in 92 patients: results and follow-up endocrine studies].

    Wiener klinische Wochenschrift·1993
    Same author

    Multicentre evaluation of the temporal bones obtained from a patient with suspected Menière's disease.

    Acta oto-laryngologica. Supplementum·1992
    Same author

    Cochlear origin of 2f1-f2 distortion products assessed by using 2 types of mutant mice.

    Hearing research·1991

    Area of Science:

    • Genetics
    • Neuroscience
    • Developmental Biology

    Background:

    • Pigment anomalies are linked to hereditary deafness.
    • Black-eyed white (BEW) mutant mice exhibit severe deafness and lack neural crest-derived melanocytes.

    Purpose of the Study:

    • To investigate the pathogenesis of pigment anomaly-associated hereditary deafness.
    • To determine the role of melanocytes in inner ear development and function.

    Main Methods:

    • Studied black-eyed white mutant mice.
    • Utilized histochemical Dopa reaction to identify melanocytes.
    • Examined inner ear structures, specifically the stria.

    Main Results:

    • BEW mice showed a thinner stria and lacked intermediate stria cells.
    • Dopa reaction confirmed intermediate stria cells are melanocyte-derived in normal mice.
    • Mutant mice lacked tyrosinase-positive reactions, indicating a lack of melanocytes.

    Conclusions:

    • The absence of melanocyte-derived intermediate stria cells is crucial in the pathogenesis of pigment anomaly-associated deafness.
    • This study highlights the link between melanocyte development and auditory function.

    Related Experiment Videos