Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

X-ray Crystallography02:18

X-ray Crystallography

24.1K
The size of the unit cell and the arrangement of atoms in a crystal may be determined from measurements of the diffraction of X-rays by the crystal, termed X-ray crystallography.
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...
24.1K
X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

3.9K
X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
3.9K
Super-resolution Fluorescence Microscopy01:37

Super-resolution Fluorescence Microscopy

7.1K
Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...
7.1K
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

13.6K
Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
13.6K
X-ray Imaging01:24

X-ray Imaging

5.9K
German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electron-ion equilibration in superheated gold.

Nature communications·2026
Same author

Increasing gonadorelin hydrochloride dose at the first GnRH of breeding Ovsynch enhances luteinizing hormone release, ovulatory response, and pregnancy in first-service lactating dairy cows.

Journal of dairy science·2026
Same author

A platform to measure isentropes from proton-heated warm dense matter on short pulse laser facilities.

The Review of scientific instruments·2025
Same author

Direct Experimental Proof of the Principal Role of Reduced High-Mode Hydrodynamic Mix in Recent Ignition Success on NIF.

Physical review letters·2025
Same author

First Demonstration of Improved Fusion Yield with Increased Compression through Reduced Adiabat in Inertial Confinement Fusion Experiments at the National Ignition Facility.

Physical review letters·2025
Same author

Superheating gold beyond the predicted entropy catastrophe threshold.

Nature·2025
Same journal

Erratum: "Highly versatile, two-color setup for high-order harmonic generation using spatial light modulators" [Rev. Sci. Instrum. 95, 073002 (2024)].

The Review of scientific instruments·2026
Same journal

Thermal correction method for accurate performance evaluation of micro-thermoelectric coolers.

The Review of scientific instruments·2026
Same journal

Correcting the energy-dependent asymmetry in low-energy muon spin rotation.

The Review of scientific instruments·2026
Same journal

Fiber-integrated acousto-optic-modulator-based phase-controlled Rydberg atomic electrometer.

The Review of scientific instruments·2026
Same journal

A top-loading point-contact spectroscopy probe with in-situ sample exchange for dilution refrigerators.

The Review of scientific instruments·2026
Same journal

Investigation of plasma characteristics in a developed large-diameter, low-aspect ratio, radio frequency plasma source with a flat spiral antenna.

The Review of scientific instruments·2026
See all related articles

Related Experiment Video

Updated: Aug 27, 2025

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
07:48

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

Published on: September 30, 2022

1.4K

Diffraction enhanced imaging utilizing a laser produced x-ray source.

M Oliver1, C H Allen2, L Divol3

  • 1Central Laser Facility, STFC Rutherford-Appleton Laboratory, Chilton, OX11 0QX, UK.

The Review of Scientific Instruments
|October 1, 2022
PubMed
Summary
This summary is machine-generated.

Researchers developed a micrometer-scale laser-generated x-ray source for probing material interfaces. This advancement enables high-resolution imaging at extreme conditions using Fresnel diffraction, paving the way for new material science discoveries.

More Related Videos

Synchrotron X-ray Microdiffraction and Fluorescence Imaging of Mineral and Rock Samples
10:12

Synchrotron X-ray Microdiffraction and Fluorescence Imaging of Mineral and Rock Samples

Published on: June 19, 2018

9.1K
Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene
08:44

Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene

Published on: August 22, 2017

7.8K

Related Experiment Videos

Last Updated: Aug 27, 2025

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue
07:48

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

Published on: September 30, 2022

1.4K
Synchrotron X-ray Microdiffraction and Fluorescence Imaging of Mineral and Rock Samples
10:12

Synchrotron X-ray Microdiffraction and Fluorescence Imaging of Mineral and Rock Samples

Published on: June 19, 2018

9.1K
Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene
08:44

Measurements of Long-range Electronic Correlations During Femtosecond Diffraction Experiments Performed on Nanocrystals of Buckminsterfullerene

Published on: August 22, 2017

7.8K

Area of Science:

  • * Physics and Materials Science
  • * X-ray Optics and Imaging

Background:

  • * Fresnel diffraction imaging uses absorption and phase-contrast to determine electron density profiles.
  • * Low coherence requirements enable laser-produced x-ray sources for this technique.
  • * Ideal for studying material interfaces under extreme conditions generated at large facilities.

Purpose of the Study:

  • * To demonstrate a proof-of-principle for an effective micrometer-scale laser-generated x-ray source.
  • * To enable high-resolution imaging of material interfaces at extreme conditions.

Main Methods:

  • * Utilized a laser-produced x-ray source (vanadium He-like, 5.2 keV) at the OMEGA Laser Facility.
  • * Employed 1 × 30 μm² and 2 × 40 μm² slits milled into 30 μm tantalum plates.
  • * Developed a 1D imaging system with micrometer-scale resolution, addressing slit taper challenges.

Main Results:

  • * Achieved an effective laser-generated x-ray source size of approximately 2 μm.
  • * Demonstrated micrometer-scale resolution by imaging a tungsten wire (2 ± 0.2 μm radius).
  • * Identified slit tilt and taper as key factors influencing source size and alignment tolerance.

Conclusions:

  • * Successfully demonstrated a viable micrometer-scale laser-generated x-ray source for Fresnel diffraction imaging.
  • * The developed system shows promise for probing material interfaces at extreme conditions with high resolution.
  • * Further optimization of slit geometry is crucial for achieving sub-micrometer source sizes.