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Updated: Aug 27, 2025
Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori
Published on: November 12, 2015
Organoids as a novel tool in modelling infectious diseases
Lucas Felipe de Oliveira1, Daniel Mendes Filho2, Bruno Lemes Marques3
1Departamento de Fisiologia, Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil; Instituto Nacional de Ciência e Tecnologia de Medicina Regenerativa, Rio de Janeiro, RJ, Brazil.
Organoid technology offers a novel approach to study infectious diseases, modeling human tissue responses and interactions with pathogens. This research explores organoids for developing new preventive and therapeutic treatments against global infectious diseases.
Area of Science:
- Biomedical research
- Infectious disease modeling
- Organoid technology
Background:
- Infectious diseases pose significant global health and societal challenges.
- Current in vitro and in vivo models have limitations in fully recapitulating human disease.
- A deeper understanding of host-pathogen interactions is crucial for effective treatments.
Purpose of the Study:
- To review the application of organoid technology in modeling infectious diseases.
- To highlight the potential of organoids in understanding pathogenesis and host responses.
- To explore organoid-based strategies for developing novel preventive and therapeutic interventions.
Main Methods:
- Utilizing organoids as multicellular culture systems that mimic human tissue architecture and function.
- Investigating host-infectious agent interactions across various organ systems (respiratory, gastrointestinal, CNS, skin).
- Analyzing the recapitulation of disease characteristics and mechanisms within organoid models.
Main Results:
- Organoids effectively model key features of human diseases, including host-pathogen interactions.
- They provide insights into pathogenesis and host responses in multiple organ systems.
- The technology demonstrates potential for studying a wide range of infectious agents.
Conclusions:
- Organoid technology is a powerful tool for advancing the study of infectious diseases.
- It facilitates the elucidation of disease mechanisms and host responses.
- Organoid models hold significant promise for the development of future treatments and preventive strategies.
