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Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
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Sex-based outcomes after surgery for acute type A aortic dissection
Sarah Yousef1, Forozan Navid1,2, Jianhui Zhu2
1Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Journal of Cardiac Surgery
|October 2, 2022
Summary
Outcomes after acute type A aortic dissection (ATAAD) repair are similar for men and women. This study found no significant differences in short- or long-term survival based on sex.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Aortic Disease
Background:
- Prior studies show inconsistent outcomes for women undergoing acute type A aortic dissection (ATAAD) repair.
- This study addresses the impact of sex on ATAAD repair outcomes.
Purpose of the Study:
- To evaluate the influence of sex on short- and long-term results after acute type A aortic dissection (ATAAD) repair.
- To compare outcomes between male and female patients undergoing ATAAD repair.
Main Methods:
- Retrospective analysis of an institutional database (2007-2021) for ATAAD repairs.
- Patient stratification by sex, Kaplan-Meier survival analysis, and multivariable Cox regression.
- Propensity score matching was employed for supplementary analysis.
Main Results:
- 601 patients (39.9% female) underwent ATAAD repair. Females were older with more comorbidities.
- Operative mortality (9.4% male vs. 13.8% female) and postoperative complications were comparable.
- No significant difference in short- or long-term survival between sexes (p=0.986).
Conclusions:
- Acute type A aortic dissection (ATAAD) repair yields similar outcomes for both sexes.
- Sex is not a significant predictor of long-term survival after ATAAD repair.
- Comparable results support equivalent management strategies regardless of patient sex.
Keywords:
aorta and great vessels
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