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Ketamine promotes adaption-induced orientation plasticity and vigorous network changes.

Ouelhazi Afef¹, Lussiez Rudy¹, Molotchnikoff Stéphane¹

¹Université de Montréal, 1375 Avenue Thérèse-Lavoie-Roux, Montréal, Quebec H2V 0B3, Canada.

|October 2, 2022

Summary

Ketamine alters neural circuit responses in the visual cortex (V1). In cats, it enhances neuronal connectivity and synchrony, while its effects vary based on adaptation levels in both mice and cats.

Keywords:

Cross correlation Ketamine Orientation selectivity Plasticity Synchrony Visual adaptation

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Area of Science:

Neuroscience
Visual System Research
Pharmacology

Background:

Primary visual cortex (V1) neurons exhibit orientation selectivity.
Adaptation or ketamine can alter neuronal tuning curves and selectivity.
The precise effects of ketamine on V1 neural circuitry remain unclear.

Purpose of the Study:

To investigate how ketamine affects orientation selectivity and neuronal functional relationships in V1.
To compare these effects in mice and cats under control, adaptation, and ketamine conditions.

Main Methods:

Electrophysiological recordings of neuronal responses to monocular stimulation.
Analysis of orientation tuning curve shifts after adaptation and ketamine application.
Pair-wise cross-correlogram analysis to assess functional connectivity and synchrony.

Main Results:

Ketamine facilitates recovery in V1 cells with large orientation shifts post-adaptation.
Ketamine amplifies orientation shifts in V1 cells with small shifts post-adaptation.
In cats, ketamine significantly increases V1 connectivity rate, strength, and neuronal synchrony, but not in mice.

Conclusions:

Ketamine differentially modulates V1 orientation selectivity based on prior adaptation.
Ketamine reshapes functional micro-circuits in the feline V1, enhancing connectivity and synchrony.
Species-specific effects of ketamine on V1 neural plasticity warrant further investigation.