Neural evidence for a separation of semantic and phonological control processes

There remain major doubts about the nature and domain specificity of inhibitory control processes, both within and between cognitive domains. This study examined inhibitory processes within the language domain, by contrasting semantic versus phonological inhibitory control. In an fMRI experiment, elderly participants performed phonological and semantic inhibitory control tasks involving resistance to highly or weakly interfering stimuli. In the semantic domain, inhibitory control effects, contrasting high vs. low interference control levels, were observed at univariate and multivariate levels in all fronto-parieto-temporal region-of-interests. In the phonological domain, inhibitory control effects were observed only at multivariate levels, and were restricted to the pars triangularis of the bilateral inferior frontal gyrus and to the left middle temporal gyrus. Critically, no reliable multivariate cross-domain prediction of neural patterns associated with inhibitory control was observed. This study supports a functional dissociation of the neural substrates associated with inhibitory control for phonological vs. semantic domains.