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Updated: Aug 27, 2025

Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
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Published on: November 17, 2014

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Role of NK T cells in transplantation with particular emphasis on corneal transplantation

Nadia Sirajuddin1, Xiao-Tang Yin1, Patrick M Stuart1

  • 1Department of Ophthalmology, Saint Louis University School of Medicine, St. Louis, MO, USA.

Transplant Immunology
|October 2, 2022
PubMed

Natural killer T cells (NKT cells) are a unique subset of the immune system that possess characteristics of both an innate and adaptive immune response. This study reviews the reported roles of NKT cells in different solid transplantations such as cardiac, skin, liver, and corneal grafts as well as investigates a novel role of NKT cells in steroid-resistant corneal rejections. It is unknown why there is late corneal graft rejection despite being treated with immunosuppression. Our experimental data suggests NKT cells are playing a crucial part in steroid-resistant late graft rejections. While the pathophysiology of acute rejection is better understood, the process of chronic graft rejection is much less clear. Our data suggests NKT cells as a potential therapeutic target to prevent chronic transplant rejection which needs further investigation.

Keywords:
CorneaNK T cells, steroid resistant rejectionTransplantation

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