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Updated: Aug 27, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
From Fleming to Endo: The discovery of statins
Adrian Chester1, Ahmed El Guindy2
1Heart Science Centre, NHLI, Imperial College London, Harefield, Middlesex, UK UB9 6JH.
Abstract:
Statins are now one of the most prescribed drugs in the world and have made a major impact to the prevention and treatment of cardiovascular disease, thereby extending the lives of millions of people across the world. The scientist responsible for the discovery of the first statin, Professor Akira Endo, was recently honoured for his 'exceptional contribution to cardiovascular medicine' by award of the European Society of Cardiology Gold Medal in 2021. Inspired by the work of Sir Alexander Fleming as a young scientist, Professor Endo pursued a long research career focusing on fungal enzymes and their potential use in medicine; a journey that eventually led him to the discovery of statins.
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