Related Experiment Video
Updated: Aug 27, 2025
07:36
Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
Published on: May 16, 2020
5.4K
4-1BB: A promising target for cancer immunotherapy
Alyssa Min Jung Kim1, Macy Rose Nemeth1, Seung-Oe Lim1,2,3
1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, United States.
Frontiers in Oncology
|October 3, 2022
Summary
Immunotherapy harnesses the immune system to treat diseases like cancer. This review focuses on 4-1BB agonists, which enhance anti-tumor immune responses, offering a promising therapeutic avenue.
Area of Science:
- Immunology
- Oncology
- Pharmacology
Background:
- Immunotherapy is a key cancer treatment, with immune checkpoint inhibitors widely used.
- Costimulatory receptor agonists, like those targeting 4-1BB, represent an area for therapeutic development to enhance anti-tumor immunity.
Purpose of the Study:
- To summarize advancements in 4-1BB targeted cancer immunotherapies.
- To provide an update on the development and clinical outlook of 4-1BB therapeutics.
Main Methods:
- Review of scientific literature on 4-1BB.
- Analysis of preclinical and clinical studies of 4-1BB agonists in cancer.
Main Results:
- 4-1BB (CD137/ILA/TNFRSF9) is a costimulatory receptor crucial for potent immune responses.
- Targeting 4-1BB enhances T cell activation and anti-tumor immunity.
- Significant progress has been made in developing 4-1BB targeting drugs.
Conclusions:
- 4-1BB agonists show promise as a next-generation cancer immunotherapy.
- Further research and clinical trials are essential to optimize 4-1BB therapies for cancer treatment.
Related Concept Videos
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
01:27Tumor Immunotherapy
642
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
642
01:30Cancer Vaccines
492
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
492
02:50Combination Therapies and Personalized Medicine
5.0K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.0K
02:38Mitogens and the Cell Cycle
6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
02:49Cancer Therapies
7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K